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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
14.24
Human Site:
S1596
Identified Species:
22.38
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1596
D
F
P
T
E
P
P
S
L
P
R
T
G
R
A
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1604
D
F
P
T
E
P
P
S
L
P
R
T
G
R
A
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1590
D
F
P
S
E
P
P
S
L
P
R
T
G
R
A
Dog
Lupus familis
XP_534241
2041
231068
S2012
D
F
T
S
E
P
P
S
L
P
R
T
G
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
A1583
D
F
T
S
E
P
P
A
L
P
R
T
G
R
A
Rat
Rattus norvegicus
P41516
1526
173202
V1502
H
V
D
L
D
D
T
V
A
P
R
A
K
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
P1895
S
D
F
S
S
E
P
P
S
L
P
R
T
G
R
Chicken
Gallus gallus
O42131
1627
183228
A1599
S
G
F
A
S
E
T
A
P
K
P
R
T
G
R
Frog
Xenopus laevis
NP_001082502
1579
178601
N1555
S
D
S
D
E
M
E
N
I
V
P
R
A
Q
A
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
L1588
G
F
N
S
F
S
H
L
D
S
G
R
D
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
R1423
K
A
P
P
K
K
R
R
A
V
I
E
S
D
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
Y1496
A
R
K
A
P
P
T
Y
D
V
D
S
G
S
D
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
G1424
S
E
D
E
E
S
D
G
S
G
E
F
V
I
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
V1449
N
R
R
K
M
T
Y
V
L
S
D
S
E
S
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1404
S
Y
V
E
T
L
E
L
S
D
D
S
F
I
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
93.3
86.6
N.A.
80
13.3
N.A.
6.6
0
13.3
13.3
N.A.
6.6
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
20
N.A.
13.3
6.6
33.3
26.6
N.A.
13.3
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
14
0
0
0
14
14
0
0
7
7
0
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
34
14
14
7
7
7
7
0
14
7
20
0
7
7
14
% D
% Glu:
0
7
0
14
47
14
14
0
0
0
7
7
7
0
14
% E
% Phe:
0
40
14
0
7
0
0
0
0
0
0
7
7
0
0
% F
% Gly:
7
7
0
0
0
0
0
7
0
7
7
0
40
14
7
% G
% His:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
7
0
7
0
0
14
0
% I
% Lys:
7
0
7
7
7
7
0
0
0
7
0
0
7
0
0
% K
% Leu:
0
0
0
7
0
7
0
14
40
7
0
0
0
0
0
% L
% Met:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
27
7
7
40
40
7
7
40
20
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
14
7
0
0
0
7
7
0
0
40
27
0
40
14
% R
% Ser:
34
0
7
34
14
14
0
27
20
14
0
20
7
20
7
% S
% Thr:
0
0
14
14
7
7
20
0
0
0
0
34
14
0
7
% T
% Val:
0
7
7
0
0
0
0
14
0
20
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
7
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _